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  1. Before you take celebrex, inform your healthcare provider of any medical conditions you may have and of all of the celebrex medications you take, including celebrex prescription or over-the-counter medicines, vitamins, or herbal supplements as they may increase the risk for serious side effects. This may happen early in treatment and may increase with increasing doses of nsaids and with longer use of nsaids. Celebrex can cause serious side effects, including: new or worse high blood pressure heart failure liver problems including liver failure kidney problems including kidney failure low red blood cells (anemia) life-threatening allergic reactions life-threatening skin reactions, other side effects.